Archive for August 21st, 2008

OMNI Postings of 8/21/08

*  The California legislature was bothered by the fact that electric and hybrid cars are so quiet that they will endanger the lives of the visually impaired.  This link will give you my Top 10 suggestions I would make to keep the visually-impaired safe.  Of course, it’ll never happen.
http://omniphysicians.com/2008/08/20/do-quiet-cars-hurt-the-visually-impaired/

*  This is the latest USA map reflecting human cases of WNV as of this week.  There are a couple of cases detected in NW Ohio and SE Michigan if you lokk at the map.  So far, there have been 236 reported cases.

http://omniphysicians.com/2008/08/21/wnv-most-recent-map/

*  File this one under technology of the future.  Technology is being developed that will detect skin cancer by the odor it emits.  The authors predict at some point there will be a little hand-held device that will do the sniffing and the reporting.  However, if the patient just ate a sardines and provolone sandwich, all bets are off.
http://omniphysicians.com/2008/08/21/detecting-skin-cancer-by-smell/

*  This is the HHS website where you can compare the death rates among hospitals in various categories [heart attack, heart failure, pneumonia, asthma (children only) or patients having surgery].  It doesn’t include hospital deaths due to cuisine.
http://omniphysicians.com/2008/08/21/website-for-rating-hospitals-death-rates/

*  California legislators have passed a bill that would require a doctor at the time of making a terminal diagnosis to explain all options, when requested by the patient.  “Sir, we just diagnosed that you’ve blown an aneurysm in your belly and you’ll be toast in an hour.  You have the option of dying here, trying to walk home, or getting a last meal in our award-winning cafeteria.  What will it be, sir…sir?…sir?…
http://omniphysicians.com/2008/08/21/legislating-talking-to-patients/

*  This abstract from Am J Med concluded that a negative 64-slice CT cardiac angiogram releaible excluded CAD.
http://omniphysicians.com/2008/08/21/64-slice-ct-for-cad/

*  What do the public and trauma professionals think about traumatic death & dying?  Some of the findings:  Most of the public and trauma professionals would prefer palliative care when doctors determine that aggressive critical care would not be beneficial in saving their lives. During resuscitation of an injured loved one, 51.9% of the public and 62.7% of the professionals would prefer to be in the emergency department treatment room. Most of the public believes that patients should have the right to demand care not recommended by their physicians. Most of both groups trust a doctor’s decision to withdraw treatment when futility is determined. More of the public (57.4%) than the professionals (19.5%) believe that divine intervention could save a person when physicians believe treatment is futile.
http://omniphysicians.com/2008/08/19/trauma-death-dying/

Take care,

Paul R.

WNV Most Recent Map

Intro:  You will note that human cases have been reported around NW Ohio and SE Michigan. 

1

1

Cumulative 2008 Data as of 3 am, Aug 19, 2008*
National Cumulative Human Disease Cases:236
These data are provisional and may be revised or adjusted in the future.

Detecting Skin Cancer by Smell

MedPage, 8/20/08 (http://www.medpagetoday.com/Dermatology/SkinCancer/tb/10613)

“Basal cell carcinoma has a characteristic odor that can be distinguished from healthy skin, researchers found.  The pattern of volatile organic compounds released by the skin at a tumor site differs from that found near healthy skin, according to Michelle Gallagher, Ph.D., of the Monell Chemical Senses Center here, and colleagues.

 

The difference can be detected using solid-phase microextraction and gas chromatography/mass spectrometry techniques, Dr. Gallagher, now at the Philadelphia chemical firm Rohm and Haas, said at the national meeting of the American Chemical Society.

 

But in the long run, it may be possible to build small hand-held devices that could detect the altered pattern of volatile compounds, Dr. Gallagher said in a statement…”

Website for Rating Hospitals’ Death Rates

This is the HHS website where you can compare the death rates among hospitals in various categories [heart attack, heart failure, pneumonia, asthma (children only) or patients having surgery].  It doesn’t include hospital deaths due to cuisine.

http://www.hospitalcompare.hhs.gov/Hospital/Home2.asp?version=alternate&browser=IE%7C6%7CWinXP&language=English&defaultstatus=0&pagelist=Home

Legislating talking to patients

Intro:   This legislation would require a doctor at the time of a terminal diagnosis to explain all options, when requested by the patient.  OK, I get it.  Now there’s a law forcing a doctor to talk to the patient.  One state senator said that a patient has a right to ask questions and a right to have them answered.  So, what do doctors who give the terminal diagnosis do now?  They just leave the patient hanging while they go outside for a smoke or to harass a nurse?  Is there a hidden message here?  Do Californians, and you know how conservative they are, want the medical profession to include instructing the patients on ways to “off” themselves?
LA Times, 8/21/08 (http://www.latimes.com/news/local/la-me-legis21-2008aug21,1,4228712.story)

Doctors who diagnose people with terminal illnesses would be required to immediately tell them about the right to refuse or withdraw from life-sustaining treatment under a measure approved Wednesday by state lawmakers.

The proposal, which divided the medical community, was narrowly approved on the same day the Legislature passed a bid to ban employers from taking action against workers who legally use marijuana for medical purposes.

The right-to-die legislation would require a doctor at the time of a terminal diagnosis to explain all options, when requested by the patient.

If you have been diagnosed as dying, you have a right to ask questions and a right to have them answered, said Sen. Sheila Kuehl (D-Santa Monica).

“Right now, all too often, your questions are brushed aside,” she said.

She called the bill, AB 2747 by Assemblywoman Patty Berg (D-Eureka), a “very modest” proposal.

However, Sen. Sam Aanestad (R-Grass Valley), an oral surgeon, said many physicians who treat cancer patients oppose the latest bill as government meddling at a time when patients need compassion.

“What they don’t need is another governmental intrusion into the relationship between themselves and their doctor,” Aanestad said.

Some of the options that would be explained may not be needed at the time of diagnosis or even for three or four years, he said.

Requiring patients to immediately receive “a laundry list developed by Sacramento politicians” may lead to rash decisions to hasten death of depressed patients before all treatment is attempted, he said.

The Senate passed the bill 21 to 17.

It was supported by groups including the California Medical Assn., AIDS Project Los Angeles and the American Civil Liberties Union. Opponents included Catholic Healthcare West, California ProLife Council and Northridge Hospital Medical Center.

The bill will go back to the Assembly for approval of minor amendments before it is sent to the governor…

The Economics of HPV Vaccination

MedPage, 8/20/08 (http://www.medpagetoday.com/HematologyOncology/OtherCancers/tb/10620): “…The cost-effectiveness of HPV vaccination in the United States will likely be optimized by achieving universal coverage in young adolescent girls and targeting initial catch-up efforts to girls and women younger than 21,” the authors said….”

In an editorial accompanying the study, Charlotte J. Haug, M.D., Ph.D., editor of the Journal of the Norwegian Medical Association, wrote that “because cervical cancer develops only after years of chronic infection with HPV…there was not yet absolute proof that protection against these two strains of the virus would ultimately reduce rates of cervical cancer — although in theory it should do so,”

Kim JJ, Goldie SJ. “Health and economic implications of HPV vaccination in the United States”                                           N Engl J Med 2008; 359: 821-832.

ABSTRACT

Background The cost-effectiveness of prophylactic vaccination against human papillomavirus types 16 (HPV-16) and 18 (HPV-18) is an important consideration for guidelines for immunization in the United States. Methods We synthesized epidemiologic and demographic data using models of HPV-16 and HPV-18 transmission and cervical carcinogenesis to compare the health and economic outcomes of vaccinating preadolescent girls (at 12 years of age) and vaccinating older girls and women in catch-up programs (to 18, 21, or 26 years of age). We examined the health benefits of averting other HPV-16–related and HPV-18–related cancers, the prevention of HPV-6–related and HPV-11–related genital warts and juvenile-onset recurrent respiratory papillomatosis by means of the quadrivalent vaccine, the duration of immunity, and future screening practices. Results On the assumption that the vaccine provided lifelong immunity, the cost-effectiveness ratio of vaccination of 12-year-old girls was $43,600 per quality-adjusted life-year (QALY) gained, as compared with the current screening practice. Under baseline assumptions, the cost-effectiveness ratio for extending a temporary catch-up program for girls to 18 years of age was $97,300 per QALY; the cost of extending vaccination of girls and women to the age of 21 years was $120,400 per QALY, and the cost for extension to the age of 26 years was $152,700 per QALY. The results were sensitive to the duration of vaccine-induced immunity; if immunity waned after 10 years, the cost of vaccination of preadolescent girls exceeded $140,000 per QALY, and catch-up strategies were less cost-effective than screening alone. The cost-effectiveness ratios for vaccination strategies were more favorable if the benefits of averting other health conditions were included or if screening was delayed and performed at less frequent intervals and with more sensitive tests; they were less favorable if vaccinated girls were preferentially screened more frequently in adulthood.

Conclusions The cost-effectiveness of HPV vaccination will depend on the duration of vaccine immunity and will be optimized by achieving high coverage in preadolescent girls, targeting initial catch-up efforts to women up to 18 or 21 years of age, and revising screening policies.

Full Text:  http://content.nejm.org/cgi/content/full/359/8/821

Balanced Billing: An ER Doc’s Perspective

My View: There’s nothing balanced about ‘balance bills’

By William K. Mallon -
The Sacramento Bee, Published 12:00 am PDT Thursday, August 21, 2008

You’ve paid your health care premiums, and now you have a bill for an additional $42 after getting stitches in the emergency room (beyond your co-pays and deductibles). This bill (called a “balance bill”) results from your health plan’s refusal to pay an out-of-network emergency physician fairly for treating you.

The emergency physician who does not have a contract with your health plan has repeatedly sent the plan a bill, which it has repeatedly refused to fairly pay. Now your health plan is passing this responsibility on to you.

This calculated practice of chronic underpayments and non-payments by health plans created balance billing in the first place, and the California Department of Managed Health Care has done little to prevent this unfair payment practice. The health plans have decided that your heart attack or your broken leg or your laceration is not as important as growing their profit margins. The health plans have decided to make their own enrollees responsible for paying twice (premiums and a balance bill), and then they villainize the physicians who care for their enrollees.

Let us not forget that these are the same health plans guilty of retroactively rescinding coverage on patients diagnosed with cancer, that regularly deny care and referral to their enrollees, all the while paying their CEOs millions.

To be sure, the need for balance billing should be eliminated. The California Chapter of the American College of Emergency Physicians, representing nearly 80 percent of California emergency physicians, is helping to craft a solution for balance billing with SB 981 by Senate President Pro Tem Don Perata. We support this bill because it ensures reasonable payment for emergency services provided by out-of-network emergency physicians.

It is notable that, while California emergency physicians support this bill, the California Association of Health Plans – an industry lobby organization purportedly committed to ending balance billing – does not.

That organization (remember whom they represent) cites an average balance bill of $300. But a survey of 83,695 visits for HMO non-contracted care in California by the California Chapter of the American College of Emergency Physicians found that the average patient payment for a balance bill was $39. At a second review, the average balance bill was $42, and the patients paid $24 for emergency physician services.

The paltry fines levied by the Department of Managed Health Care against the bad-acting plans are evidence of their woeful lack of regulation and apparent unwillingness to protect patients. For example, in 2005, the department found HealthNet guilty of underpayments to non-contracted emergency physicians in the amount of approximately $6 million to $7 million but fined the plan only $250,000, which when combined with repayments amounted to a net profit for HealthNet of approximately $5 million to $6 million.

California is already last in the nation in the number of emergency- room beds per capita. No fewer than 70 emergency rooms have closed in California since 1996, with more teetering on the brink. The department’s new regulations will simply further erode the safety net and make the nearest emergency room farther away from you and your loved ones.

Emergency physicians want to get back to the business of saving lives and caring for Californians, not haggling with insurance bureaucrats about receiving fair payment.

The discussion on balance billing should focus on the real problems, which are:

• Systematic, abusive payment patterns by health care plans.

• The failure of the department to regulate the plans on behalf of Californians and health care providers.

Fortunately for Californians, emergency physicians will continue to do their job 365/24/7, no matter how badly the plans behave and regardless of the department’s failure to regulate.

Turning embryonic stem cells into red blood cells

LA Times, 8/21/08 (http://www.latimes.com/news/science/la-sci-blood20-2008aug20,1,6335150.story)

Scientists said Tuesday that they had devised a way to grow large quantities of blood in the lab using human embryonic stem cells, potentially making blood drives a thing of the past.

But experts cautioned that although it represented a significant technical advance, the new approach required several key improvements before it could be considered a realistic alternative to donor blood.

The research team outlined a four-step process for turning embryonic stem cells into red blood cells capable of carrying as much oxygen as normal blood. The procedure was published online by the journal Blood.

The ability to make blood in the lab would guarantee that hospitals and blood banks have access to an ample supply of all types of blood, including the rare AB-negative and the universal donor type, O-negative.

It would also ensure that patients are never at risk of contracting diseases such as hepatitis C or HIV from donor blood, said Dr. Dan Kaufman, associate director of the University of Minnesota’s Stem Cell Institute, who wasn’t involved in the study.

“People don’t usually think about these types of cells when they talk about human embryonic stem cell therapy, but it is important,” Kaufman said. “There’s more infections all the time, and the number of donors is more and more limited.”

Researchers have tried to harness the so-called adult stem cells that are responsible for making blood in the body, but their methods were far too inefficient to be put to practical use, experts said.

In the new study, researchers were able to make as many as 100 billion red blood cells — enough to fill two or three collection tubes — from a single plate of embryonic stem cells.

After allowing the stem cells to begin the earliest stages of embryonic development, the researchers prompted some of them to grow into red blood cells by exposing them to a variety of proteins.

Up to 65% of the resulting cells matured to the point at which they shed their nucleus, which allows them to take on the distinctive doughnut shape of circulating red blood cells, said Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology Inc. and the study’s senior author.

The team, which also included researchers from the University of Illinois at Chicago and the Mayo Clinic in Rochester, Minn., produced blood of types A-positive, A-negative, B-positive, B-negative and O-positive.

The method was 100 times more efficient than previous efforts, said Eric Bouhassira, a professor of stem cell biology and regenerative medicine at Albert Einstein College of Medicine in New York. But most of the cells had embryonic or fetal versions of globin, the compound in red blood cells that carries oxygen. Only a relative few appeared to contain the adult globin that would be needed by patients, he said.

“Whether they would be good enough for transfusion is very unclear,” said Bouhassira, who wasn’t involved in the study. Lanza said the research team was conducting more experiments to see whether the stem cells would produce more adult globin if given more time to mature in the lab.

Even with substantial improvements, the method faces another big hurdle. Roger Dodd, director of the American Red Cross’ Holland Laboratory in Rockville, Md., said that producing blood in the lab could cost thousands of dollars per unit — far too expensive to replace the 14 million pints of red blood cells that are transfused every year. “It’s a rather ambitious goal,” Dodd said.

 

The “Bogus” Admit

Washington Times, 8/20/08 (http://www.washingtontimes.com/news/2008/aug/20/bogus-er-visits-ail-hospitals/)

Some hospital doctors and administrators say the quality of care they are able to offer is under siege by an insider group no one would expect: patients.

Dr. Daniel Durano, a radiology resident at Johns Hopkins Hospital in Baltimore, said a class of patients, dubbed “bogus admits” by physicians, are admitted through the emergency room when it is not clinically justified.

Patients like Irena, whose name has been changed to protect her privacy, frustrated Dr. Durand when he began practicing at Hopkins last year as a general medicine intern. Irena arrived at the ER complaining of chest pains and shortness of breath. A few hours later, she was admitted to a general medicine ward, and it fell to Dr. Durand to determine whether she had suffered a heart attack. He quickly realized she had been hospitalized for a case of heartburn.

Instead of getting a restful night’s sleep at home, Irena was subjected to extensive medical work-ups and faced exposure to hospital-borne illnesses. As for financial ramifications, Irena, her insurance company or the government likely would receive a much larger bill. Because Dr. Durand had to write notes, orders and assessments on Irena, he spent less time looking after his other patients.

Dr. Durand said there is no easy way to address the problem.

“Doctors are held to such an exacting standard by the public and the law that they act very conservatively and want to admit too many people to the hospital,” Dr. Durand said. “This drives the cost of care up and strains resources so that we can do less of what we do well: treat disease.”

A private-sector hospital study by the Michigan Health Care Education and Research Foundation in 1987 reviewed a random sample of patient records from 21 hospitals in southern Michigan. Of the 1,226 records examined, 430 revealed erroneous patient admissions, suggesting that 35 percent of the admissions were clinically unnecessary.

Rates of improper admissions in publicly funded hospitals are even higher. An Iowa Health Services Research and Development Field Program study in 1991 found that 43 percent of medical/surgical admissions to Veterans Affairs hospitals were unnecessary. This study reviewed 6,063 patient medical records from a random sample of 50 Veterans Affairs hospitals from across the country.

Dr. Peter Hill, clinical director of the Department of Emergency Medicine at Hopkins, said a review of ER doctors’ decisions to admit patients amounts to a medical version of Monday-morning quarterbacking.

“It’s a problem with perspective,” said Dr. Hill, who has served on the faculty since 1998.

Lab results and medical records can make it clearer that the patient is not at risk, but they often are not available before the patient must be moved out of the ER.

Irena had mentioned to a physician’s assistant that her family had a “history of heart disease,” Dr. Durand said. Although her symptoms fit a non-cardiac cause – chest pain that worsened when lying down and was exacerbated by spicy foods – the physician’s assistant admitted her based on the family history.

Dr. Durand later discovered, however, that Irena’s “family history” consisted of several distant relatives who died in their late 60s and early 70s. This suggested the physician’s assistant had attached too much weight to what Irena had said, but is “bogus admission” an accurate label here?

Criteria-based instruments are designed to help Medicare, Medicaid and insurance companies determine retrospectively whether to pay for services, Dr. Hill said, but give ER physicians no clear explanation of the criteria parameters for admission.

Dr. Hill cites another line of defense: the grow ing number of ER observation units at U.S. hospitals over the past 20 years. One was created at Hopkins in 2001 to buy additional time to monitor patients.

The 16 beds in the unit at Hopkins hold 4,000 to 6,000 observation patients in a given year, Dr. Hill said. Once additional information can be gathered on the patient, 75 percent are discharged without being admitted.

By creating arbitrary clinical thresholds, Medicaid, Medicare and insurance companies may have made it harder for ER doctors to stave off unnecessary admissions, Dr. Hill said.

ER observation units have reduced the number of one-day admissions, which often are perceived as bogus admits. Dr. Hill said this drop had a negative impact on the quality-of-care reports for other departments because the removal of one-day admissions caused a spike in length-of-stay averages for general medicine. He said the hospital administration then asked for a return of one-day patient admissions.

“We did it; the ER helped them,” Dr. Hill said.

How? By agreeing to admit more patients with borderline chest pain to inpatient care. The hospital administration was asking Dr. Hill to admit a patient group that had regularly been labeled as “bogus” – patients like Irena.

This move appears to have a financial incentive as well. Maryland is a capitated state – meaning insurers pay essentially the same for chest-pain patients whether they stay for one day or five – so the loss of one-day admissions was taking a toll on the hospital’s bottom line.

The debate over whether erroneous admissions are legitimate concerns is creating conflicting approaches to care. ER doctors have the power to admit, just not the time to fully diagnose, whereas the internal medicine doctors have the time needed to properly diagnose a patient, but not the ability to choose whom to admit.

Dr. Hill said ER doctors need flexibility in determining when to admit patients to their own observation units and that removing thresholds to pay for care would make economic sense.

Studies suggest that placing patients with chest pain in observation units instead of admitting them to the hospital saves about $500 to $1,200 per patient.

Affording Health Care

HealthDay, 8/21/08 (http://www.healthday.com/Article.asp?AID=618599)

“Working-age Americans are facing mounting problems when it comes to affording health care, a result of what analysts are calling a “perfect storm” of economic woes.

In 2007, 41 percent of working-age Americans — 72 million people — reported having medical bill problems or trouble paying off medical debts, up from 34 percent in 2005.

Another 7 million adults over 65 had similar problems, bringing the total to 79 million adults struggling to pay health-care bills, according to a new study from The Commonwealth Fund, Losing Ground: How the Loss of Adequate Health Insurance Is Burdening Working Families

…The survey, based on telephone interviews conducted between June 6 and Oct. 24, 2007 with 3,501 adults aged 19 and older in the continental U.S, found problems across multiple fronts:

  • In 2007, nearly two-thirds of U.S. adults under 65 (116 million people) reported having problems with medical bills or debt, having put off needed care due to cost, or being uninsured or underinsured and consequently having high out-of-pocket medical costs relative to their income.
  • Although such problems were seen across the board, they were particularly pronounced among low- and moderate-income families. More than half of adults earning less than $40,000 annually reported problems paying medical bills or being in debt as a result of health care expenses.
  • Thirty-nine percent of people with mounting bills or debts said they had depleted their savings to pay off bills; 29 percent were having problems paying for food, heat, rent and other basic necessities; and 30 percent had accumulated credit card debt.
  • Many are also foregoing medical care, including medications: 45 percent of adults reported problems getting care because of rising costs (up from 29 percent in 2001).
  • One-third of respondents reported spending 10 percent or more of their income on medical costs, including premiums, in 2007, up from 21 percent in 2001.
  • About one-quarter of working-age adults with medical debt owe $4,000 or more while 12 percent owe $8,000 or more in medical expenses.
  • Twenty-eight percent of working-age U.S. adults (about 50 million people) were uninsured for at least part of 2007, up from 24 percent in 2001.
  • Fourteen percent of working-age adults (25 million people) were underinsured, up from 9 percent in 2003.
  • Sixty-one percent of those with medical bill problems or accumulated medical debt were insured at the time care was provided. “Even adults with insurance reported problems in getting needed care,” Collins noted.

For more on the findings, head to The Commonwealth Fund.
 

64-Slice CT for CAD

64-Slice CT for Diagnosis of Coronary Artery

 Disease: A Systematic Review

 

From AM J Med

Volume 121, Issue 8, Pages 715-725

 

Abstract 

Purpose

The purpose of this systematic review was to assess the accuracy of 64-slice CT coronary angiography for the diagnosis of coronary artery disease.

Methods

We attempted to identify all published trials in all languages that used 64-slice CT to diagnose coronary artery disease. Results of 64-slice CT coronary angiography were compared with invasive coronary angiography or intravascular ultrasound.

Results

Sensitivity of 64-slice CT for significant (≥50%) stenosis, based on pooled data from all studies, was ≥90% in patient-based evaluations, named vessels, segments, and coronary artery bypass grafts, except the left circumflex (sensitivity 88%), distal segments (80%), and stents (88%). Specificity was 88% in patient-based evaluations, and ≥90% at individual sites. Positive predictive values for patient-based evaluations, left main coronary artery, and coronary artery bypass grafts ranged from 91% to 93%, but elsewhere ranged from 69% to 84%. Negative predictive values were 96% to 100%. Positive likelihood ratios for patient-based evaluations were 8.0 and, at specific sites, were ≥9.7. Negative likelihood ratios, except for distal segments, were <0.1.

Conclusion

Negative 64-slice CT reliably excluded significant coronary disease. However, the data suggest that stenoses shown on 64-slice CT require confirmation. Combining the results of 64-slice CT with a pre-CT clinical probability assessment would strengthen the diagnosis. Due to the risk of radiation-induced cancer, patients should be selected carefully for this test, and scan protocols should be optimized to minimize risk.