Archive for November 8th, 2008
3-Week-Old: Fever & Rash
http://www.idinchildren.com/200511/spot.asp
This 3-week-old infant presented to the emergency room with a two-day history of fever and rash. On physical exam, he had a temperature of 100.4°F and was irritable, particularly when his skin was palpated. Marked facial edema was present as well as perioral radial furrowing. A generalized erythema with a fine stippled sandpaper appearance was accentuated in the flexural folds.

DISCUSSION: This is staphylococcal scalded skin syndrome (SSSS), also known as Ritter’s disease. It is caused by an exfoliative toxin produced by certain strains of Staphylococcus aureus, most commonly phage group II. The elaborated S. aureus exotoxin enters the circulation, eventually reaching and binding to the mid-epidermis. It targets desmoglein-1, a desmosomal component that promotes cell-to-cell adhesion. The toxin causes disruption of these attachments, leading to a cleavage plane in the epidermis, with subsequent blistering and exfoliation of the superfi cial aspect of the skin.
SSSS typically begins with one to two days of fever and irritability followed by a generalized tender erythema. The characteristic rash is sandpaper-like, accentuated in the flexural folds and extremely tender to palpation. Fragile blisters then develop. Nikolsky’s sign is positive, which refers to the tendency toward separation of the upper epidermis with gentle pressure. Mucosal surfaces are spared, resulting in the characteristic perioral furrowing with a line of demarcation between the lips and surrounding edematous skin. There is a spectrum of disease severity, ranging from localized bullous impetigo to a generalized exfoliation of nearly the entire body surface area.
This syndrome most frequently affects neonates and children younger than 5. Various theories suggest that this is both due to a naive immune system and relatively decreased renal clearance of toxin. In the rare case that it is seen in adults, it is usually associated with a predisposition, such as immunosuppression or renal failure. Extent of disease in a given individual has been linked to the body’s ability to produce anti-toxin antibodies, the amount of toxin elaborated vs. excreted, and whether it is released locally or systemically.
Though SSSS can occur in association with a focus of infection such as conjunctivitis, pneumonia or endocarditis, it often results from colonization at sites such as the nares, umbilicus or perineum. In fact, a nosocomial outbreak has been reported which was attributed to carriage of toxin-producing S. aureus on the hands of a health care worker.
Diagnosis can often be made by clinical appearance alone, but cultures should be obtained from the blood as well as any suspected focus of infection, such as conjunctivae, nasopharynx, umbilicus, rectum or wound site. In childhood cases, a detection rate of S. aureus in blood cultures as low as a 3% has been noted. Fluid from bullae are also typically sterile. Various mechanisms for isolating the exfolative toxins exist, including polymerase chain reaction, ELISA and slide latex agglutination. A skin biopsy would reveal epidermal splitting at the granular layer without necrosis.
The differential diagnosis of SSSS primarily includes other toxin-mediated erythemas (scarlet fever), drug reactions (toxic epidermal necrolysis) and primary dermatoses (atopic dermatitis). Of note, in toxic epidermal necrolysis, the mucous membranes are involved, and biopsy would reveal a level of cleavage below the epidermis as well as full-thickness epidermal necrosis. Other less common considerations include congenital ichthyoses (bullous congenital ichthyosiform erythroderma), blistering disorders (pemphigus foliaceus), immunodeficiencies (Omenn’s syndrome), and nonaccidental injuries (scalding, chemical burn).
Treatment involves antibiotics, pain control, skin care with barrier ointments and fluid and electrolyte management. An IV penicillinaseresistant penicillin, such as nafcillin, should be administered. Several cases associated with MRSA have been reported, and this should be considered if there is no response to empiric antibiotic treatment. In addition, due to the compromised barrier function of the blistered and exfoliating epidermis, one must take care to protect against hypothermia, dehydration and secondary infections, which can be fatal complications, particularly in infants.
Prognosis is generally much better for infants than adults, with a 4% mortality rate vs. at least 60% in the latter group, likely because of serious underlying comorbidities in affected adults. After appropriate antibiotic treatment is initiated, exfoliation continues for up to 48 hours. Due to the superficial nature of the skin lesions, they tend to heal rapidly within one to two weeks without scarring.
For more information:
- Ladhani S. Recent developments in staphylococcal scalded skin syndrome. Clin Microbiol Infect. 2001;7:301-307.
- Patel GK, Finlay AY. Staphylococcal scalded skin syndrome: diagnosis and management. Am J Clin Dermatol 2003;4:165-175.
- El Helali N, Carbonne A, Naas T, et al. Nosocomial outbreak of staphylococcal scalded skin syndrome in neonates: epidemiological investigation and control. J Hosp Infect. 2005;61:130-138.
- Farrell AM. Staphylococcal scalded-skin syndrome. Lancet. 1999;354:880-881.
- Hoeger PH, Harper JI. Neonatal erythroderma: differential diagnosis and management of the “red baby.” Arch Dis Child 1998;79:186-191.
- Sterry W, Muche JM. Erythroderma. Dermatology. 2005:165-174.
Eating & Exercising Healthier
LA Times, 11/7/08 (http://latimesblogs.latimes.com/booster_shots/2008/11/encouraging-new.html)
Those copious messages about maintaining healthy lifestyles must be sinking in, because Americans are getting a little savvier about eating right and exercising.
So says the latest public opinion survey from the American Dietetic Assn., “Nutrition and You: Trends 2008.” The nationwide study asked 783 men and women their attitudes on healthful eating, the importance of diet and exercise, and even delved into reasons why people don’t do more to get healthy.
When asked about overall attitudes on maintaining a healthful diet and engaging in regular exercise, 43% said, “I’m already doing it,” and engaging in good behaviors. In 2002, that number was 38%. People in the “I know I should” category — those who understand a healthy lifestyle is critical but haven’t done anything significant to achieve it — was 38%, up from 30% in 2002. And 19% of men and women put themselves in the “don’t bother me” category, not believing that diet and exercise are important. That’s down from 32% in 2002, suggesting a mind-set change.
Participants were asked to rank major and minor reasons for not wanting to do more to attain a balanced diet; 79% said they’re satisfied with the way they eat, and 73% said they don’t want to give up the foods they like. Only 41% said it was because they didn’t understand diet and nutrition guidelines. Those numbers haven’t changed drastically in eight years.
But people do seem to want more information on nutrition and healthful eating. In 2008, 40% said they were actively seeking more news, up from only 19% in 2000. And they’re making different choices: in the last five years, the number of people who increased their consumption of whole-grain foods rose 56%; vegetables, 50%; fruits, 48%; fish, 43%; and chicken, 42%. Those decreasing their intake of beef decreased 41%; dairy, 23%; and pork, 33%.
Messages about whole grains being better for you than refined white flour are definitely getting through — 94% of people ranked whole-grain bread healthier than white bread, while 6% said it was just as healthful. Six people (less than 1%) declared white bread healthier than whole grain.
“I definitely think the findings are encouraging,” says Jeannie Gazzaniga-Moloo, an ADA spokeswoman and Roseville, Calif.-based registered dietitian. “Consumers are saying that diet, nutrition and physical activity are important to them, and we’ve seen a growth in that. We’ve also seen more people fall into the category of doing what they can to [maintain a healthy lifestyle]. But we know from rates of chronic diseases such as diabetes and heart disease that there is more that can be done.”
Gazzaniga-Moloo is concerned that many people still believe they have to give up the foods they enjoy in order to be healthier. “There’s still a big misconception about that,” she says. “You don’t have to give up those foods — you can look at portion size and frequency of eating them. They can be worked into a healthy, balanced diet.”
But she’s cheered by the fact that people are adding more fruits and vegetables to their diets and adds, “It’s one step at a time. Even just adding a serving to two or three meals a day is a step in the right direction.”
Ignorance of Pre-Diabetes
HealthDay, 11/6/08 (http://www.healthday.com/Article.asp?AID=621129)
Too many American adults are unaware of “pre-diabetes” and not enough take action to reduce their risk, according to a U.S. Centers for Disease Control and Prevention study released Thursday.
People with pre-diabetes — a condition in which blood glucose levels are higher than normal but not high enough to be classified as diabetes — are at increased risk for developing type 2 diabetes, heart disease and stroke. But lifestyle changes such as diet and exercise can prevent or delay development of diabetes and its complications.
More than 25 percent of Americans have pre-diabetes but, in 2006, only 4 percent of adults had ever been told they had the condition, said the CDC researchers, who analyzed data on about 24,000 adults who took part in the 2006 U.S. National Health Interview Survey.
There are five conditions indicative of pre-diabetes — pre-diabetes itself, impaired fasting glucose, impaired glucose tolerance, borderline diabetes, and high blood sugar. Of the 984 people in the study who’d been told they had pre-diabetes, 64.4 percent were told they had borderline diabetes, 38.3 percent were told they had high blood sugar, 33.7 percent were told they had pre-diabetes itself, 15.5 percent were told they had impaired glucose tolerance, and 15. 2 percent were told they had impaired fasting glucose. In addition, 43.3 percent were told they had two or more of the five conditions.
Rates of pre-diabetes increased with age, ranging from 2.7 percent among those ages 18 to 44 to 6 percent among those over age 65. Rates also increased with weight — 2.3 percent among those with normal weight, 3.9 percent among those who were overweight, and 6.3 percent among those who were obese.
The study also found that pre-diabetes was more common among women (4.8 percent) than men (3.2 percent), but found no significant race/ethnicity-related differences.
Of the 984 people who’d been told they had pre-diabetes, 68 percent tried to lose or control weight, 55 percent increased their levels of physical activity, and 60 percent reduced their intake of dietary fat or calories. Only 42 percent engaged in all three risk reduction activities, and 24 percent didn’t participate in any of these activities, the study found.
The study was published in this week’s issue of the Morbidity and Mortality Weekly Report, a CDC journal. It echoes a prior study, published in the same journal on Oct. 31, that found that the U.S. rate of new cases of full-blown type 2 diabetes has doubled over the past decade from 4.5 cases per 1,000 people in 1995-1997, to 9.1 cases per 1,000 people by 2007. The suspected cause: rising obesity rates.
It’s not too late to turn those numbers around, experts said. “An important opportunity exists to reduce the preventable burden of diabetes and its complications by increasing awareness of pre-diabetes among those who have the condition, and encouraging the adoption of healthier lifestyles and risk reduction activities among all U.S. adults,” the researchers wrote in a summary of their study.
They added that people at increased risk for diabetes should lose or control their weight, increase their physical activity levels, and be tested according to published recommendations.
Congress: 14 Physicians (At least)
Wall Street Journal (11/7) reports, “There will be at least 14 medical doctors in the 111th Congress, an addition of two seats from the current session, according to the American Medical Association.” The group said that “all nine docs who ran for re-election in the House held on to their seats.” In addition, “there are two physicians in the Senate: Tom Coburn (R-OK), wasn’t up for re-election; John Barrasso (R-WY), was appointed in 2007, and won in a special election Tuesday.” Of the physicians, 10 are Republicans and four are Democrats. But, Michael Burgess, M.D., “a Texas OB-GYN first elected to the House in 2002,” noted that “there aren’t enough doctors in Congress” to influence healthcare reform. “It leaves us with a pretty narrow group of individuals, and it’s a little harder to build consensus on common ground,” he said.
Risk Factors for Perioperative Death and Stroke After Carotid Endarterectomy
Halm EA, et al “Risk Factors for Perioperative Death and Stroke After Carotid Endarterectomy: Results of the New York Carotid Artery Surgery Study” Stroke 2009; 40:000-000.
ABSTRACT
Background and Purpose—The benefit of carotid endarterectomy is heavily influenced by the risk of perioperative death or stroke. This study developed a multivariable model predicting the risk of death or stroke within 30 days of carotid endarterectomy.
Methods—The New York Carotid Artery Surgery (NYCAS) Study is a population-based cohort of 9308 carotid endarterectomies performed on Medicare patients from January 1998 through June 1999 in New York State. Detailed clinical data were abstracted from medical charts to assess sociodemographic, neurological, and comorbidity risk factors. Deaths and strokes within 30 days of surgery were confirmed by physician overreading. Multivariable logistic regression was used to identify independent patient risk factors.
Results—The 30-day rate of death or stroke was 2.71% among asymptomatic patients with no history of stroke/transient ischemic attack (TIA), 4.06% among asymptomatic ones with a distant history of stroke/TIA, 5.62% among those operated on for carotid TIA, 7.89% of those with stroke, and 13.33% in those with crescendo TIA/stroke-in-evolution. Significant multivariable predictors of death or stroke included: age > 80 years (OR, 1.30; 95% CI, 1.03 to 1.64), nonwhite (OR, 1.83; 1.23 to 2.72), admission from the emergency department (OR, 1.95; 1.50 to 2.54), asymptomatic but distant history of stroke/TIA (OR, 1.40; 1.02 to 1.94), TIA as an indication for surgery (OR, 1.81; 1.39 to 2.36), stroke as the indication (OR, 2.40; 1.74 to 3.31), crescendo TIA/stroke-in-evolution (OR, 3.61; 1.15 to 11.28), contralateral carotid stenosis >50% (OR, 1.44; 1.15 to 1.79), severe disability (OR, 2.94; 1.91 to 4.50), coronary artery disease (OR, 1.51; 1.20 to 1.91), and diabetes on insulin (OR, 1.55; 1.10 to 2.18). Presence of a deep carotid ulcer was of borderline significance (OR, 2.08; 0.93 to 4.68).
Conclusions—Several sociodemographic, neurological, and comorbidity risk factors predicted perioperative death or stroke after carotid endarterectomy. This information may help inform decisions about appropriate patient selection, assessments about the impact of different surgical processes of care on outcomes, and facilitate comparisons of risk-adjusted outcomes among providers.
Non-Paying Patients: More Than Ever
NY Times, 11/7/08 (http://www.nytimes.com/2008/11/07/business/07hospital.html?_r=1&oref=slogin&partner=rssnyt&emc=rss&pagewanted=print)

While the full effects of the downturn are likely to become more evident in coming months as more people lose their jobs and their insurance coverage, some hospitals say they are already experiencing a fall-off in patient admissions.
Some patients with insurance seem to be deferring treatments like knee replacements, hernia repairs and weight-loss surgeries — the kind of procedures that are among the most lucrative to hospitals. Just as consumers are hesitant to make any sort of big financial decision right now, some patients may feel too financially insecure to take time off work or spend what could be thousands of dollars in out-of-pocket expenses for elective treatments.
The possibility of putting off an expensive surgery or other major procedure has now become a frequent topic of conversation with patients, said Dr. Ted Epperly, a family practice doctor in Boise, Idaho, who also serves as president of the American Academy of Family Physicians. For some patients, he said, it is a matter of choosing between such fundamental needs as food and gas and their medical care. “They wait,” he said.
The loss of money-making procedures comes at a difficult time for hospitals because these treatments tend to subsidize the charity care and unpaid medical bills that are increasing as a result of the slow economy.
“The numbers are down in the past month, there’s no question about it,” said Dr. Richard Friedman, a surgeon at Beth Israel Medical Center in New York, although he said it said it was too early to call the decline a trend.
But many hospitals are responding quickly to a perceived change in their circumstances. Shands HealthCare, a nonprofit Florida hospital system, cited the poor economy and lower patient demand when it announced last month that it would shutter one of its eight hospitals and move patients and staff to its nearby facilities.
The 367-bed hospital that is closing, in Gainesville, lost $12 million last year, said Timothy Goldfarb, the system’s chief executive. “We cannot carry it anymore,” he said.
Some other hospitals, while saying they have not yet seen actual declines in patient admissions, have tried to curb costs by cutting jobs in recent weeks in anticipation of harder times. That includes prominent institutions like Massachusetts General in Boston and the University of Pittsburgh Medical Center, as well as smaller systems like Sunrise Health in Las Vegas.
“It’s safe to say hospitals are no longer recession-proof,” said David A. Rock, a health care consultant in New York.
A September survey of 112 nonprofit hospitals by a Citi Investment Research analyst, Gary Taylor, found that overall inpatient admissions were down 2 to 3 percent compared with a year earlier. About 62 percent of the hospitals in the survey reported flat or declining patient admissions.
Separately, HCA, the Nashville chain that operates about 160 for-profit hospitals around the country, reported flat admissions for the three months ended Sept. 30 compared with the period a year earlier, and a slight decline in inpatient surgeries.
Many people are probably going to the hospital only when they absolutely need to. “The only way they are going to tap the health care system is through the emergency room,” Mr. Taylor said.
And now, as the economy has slid more steeply toward recession in recent weeks, patient admissions seem to have declined even more sharply, some hospital industry experts say. “What we have not seen through midyear this year is the dramatic slowdown in volume we’re seeing right now,” said Scot Latimer, a consultant with Kurt Salmon Associates, which works closely with nonprofit hospitals.
While the drop-off in patient admissions may still seem relatively slight, hospital executives and consultants say it is already having a profound impact on many hospitals’ profitability. As fewer paying customers show up, there has been a steady increase in the demand for services by patients without insurance or other financial wherewithal, many of whom show up at hospital emergency rooms — which are legally obliged to treat them.
“It’s disproportionately affecting the bottom line,” Mr. Latimer said.
In California, for example, the amount of bad debt and charity care among hospitals has been steadily climbing, to $7.1 billion last year from about $5.8 billion in 2005. Those numbers could approach $8 billion for 2008, according to an analysis by Kurt Salmon.
The situation is exposing a main vulnerability of the nation’s hospital care system, which executives say relies heavily on private insurance to subsidize certain services. When there is a decline in profitable procedures paid for by private insurance, hospitals have less money to offset the relatively lower fees they receive from government insurance programs like Medicare and Medicaid.
“What happens in our country is that there’s really a hidden tax built in,” said Richard L. Gundling, an executive with a trade group for hospital financial executives, the Healthcare Financial Management Association. “Hospitals have to balance the mix of patients in order to survive.”
The amount of charity care provided by Shands HealthCare, the operator of the Gainesville hospital, has doubled in the last four years, to $115 million in fiscal 2008, Mr. Goldfarb said. He worries that the financial outlook will become even worse, with the prospect of payment cuts from state governments that are facing large budget shortfalls.
“If we’re going to survive the next few years,” he said, “we have to circle the wagons.”
The rapid moves by hospitals to cut costs — by laying off workers, consolidating facilities and freezing construction and other capital spending — are an abrupt change for an industry traditionally seen as insulated from economic woes.
Some hospital executives say they are simply being prudent. The University of Pittsburgh Medical Center, for example, is eliminating 500 jobs. The hospital system, which includes 20 hospitals and serves a large portion of Medicare and Medicaid patients, says that so far it has not seen a drop in patient admissions, but growth is tailing off.
“It’s much, much slower than we’ve seen in years past,” said Robert A. DeMichiei, Pittsburgh’s chief financial officer.
Mr. DeMichiei said Pittsburgh was mainly trying to reduce administrative jobs as a way to keep ahead of the worsening economy. Because large hospital groups like his have become more professionally managed in recent years, he said, they are no longer slow to reduce expenses.
Hospital executives “are beginning to act more like Corporate America,” said Mr. DeMichiei, whose own résumé includes various jobs at General Electric.
Another source of financial anxiety, hospitals say, is the continued difficulty in raising money through the credit markets. The majority of the nation’s hospitals are nonprofit, and they often raise capital through the municipal bond market to erect new buildings or make other significant capital investments. Because many hospitals say they are still unable to borrow easily, they have reacted by scaling back projects or holding off on major purchases.
“We are being extremely cautious about approving spending in these 60 to 90 days, until the markets stabilize,” said Michael A. Slubowski, the president of hospital and health networks for Trinity Health, a large Catholic system based in Novi, Mich., which operates nearly four dozen hospitals, mostly scattered across the Midwest.
While Trinity says it has not seen an overall reduction in its patient admissions, Mr. Slubowski says many of his counterparts have. “People are seeing declines,” he said.
Making matters worse for some hospitals has been a slowdown in bill payments, particularly by state Medicaid programs. The money hospitals are owed for their services — their accounts receivable — is growing, said Mr. Rock, the health care consultant, who works for the investment and consulting firm Carl Marks & Company in New York. “What we’re finding is one of the key drivers is Medicaid,” he said.
Many hospital executives also expect outright reductions in payments by Medicaid and Medicare.
Mr. Rock predicts that many hospitals will soon start to reconsider the services they provide, with an eye toward scaling back or eliminating some altogether. Procedures that rely heavily on patients’ making sizable cash outlays, like bariatric surgery, are particularly vulnerable, he said.
Hospital executives concede that they may not be as directly affected by the weak economy as retailers and banks, but they also say they are bracing for what is shaping up to be a severe and prolonged recession.
“There’s a lot of C.F.O. doom and gloom,” said Robert Shapiro, the chief financial officer at North Shore-Long Island Jewish Health System. “The sky may be really falling this time.”
Insulin Syringe Recall
Class 1 Recall: Tyco Healthcare Group LP (Covidien), ReliOn Insulin Syringes, 1cc, 31-Gauge
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Date Recall
Initiated: |
October 9, 2008 |
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Product:
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ReliOn Insulin Syringes, 1cc, 31-gauge, 100 units for use with U-100 insulin, Lot Number 813900, Product Code 38396-0403-02
Only ReliOn syringes from this lot number and labeled as 100 units for use with U-100 insulin are subject to this recall. This product was manufactured in June 2008 and distributed from July through October 8, 2008. |
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Use:
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An insulin injection is used to control blood sugar in people who have type 1 or type 2 diabetes and who cannot control their diabetes with oral medicines. |
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Recalling Firm:
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Covidien LP 15 Hampshire St Mansfield, Massachusetts 02048-1113 |
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Reason for Recall:
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Some packages were mislabeled. The syringes labeled for use with U-40 unit insulin were mixed with syringes labeled for use with U-100 insulin. The use of these syringes may lead to patients receiving an overdose of as much as 2.5 times the intended dose, which may lead to hypoglycemia (abnormally low level of blood sugar), serious health consequences, and even death. |
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Public Contact:
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Customers may return the recalled product to their local Wal-Mart store or Sam’s Club pharmacy for replacement product. Consumers and healthcare professionals who suspect they have the recalled product may also contact Covidien at 1-866-780-5436 or www.relion.com/recall for more information. |
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FDA District:
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New England |
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FDA Comment:
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Tyco Healthcare Group, LP (Covidien) notified Can-Am Care, Corporation (the distributor of these syringes) by letter sent by e-mail and by Federal Express on October 9, 2008. The letter requests that they immediately:
Can-Am Care, whose name appears on the product label, has also posted a notice on their website. Wal-Mart and Sam’s Clubs conducted consumer mailings on Oct. 14, 2008, posted the recall announcement in their stores, and on Wal-Mart’s website, and are posting placards (posters) in their stores. Wal-Mart and Sam’s Club are asking their customers to return ReliOn 1cc, 31-gauge syringes labeled as 100 units for use with U-100 insulin from Lot Number 813900 to their local Wal-Mart store or Sam’s Club pharmacy for a replacement product. For additional information, see FDA’s Press Release at http://www.fda.gov/bbs/topics/NEWS/2008/NEW01911.html Class 1 recalls are the most serious type of recall and involve situations in which there is a reasonable probability that use of these products will cause serious injury or death. Health care professionals and consumers may report adverse reactions or quality problems experienced with the use of these products to the FDA’s MedWatch Adverse Event Reporting program either online, by regular mail or by FAX.
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BioThreat Package
“Model Procedures for Responding to a Package with Suspicion of a Biological Threat” International Association of Fire Chiefs (In cooperation with FBI Hazardous Materials Response Unit, FBI Laboratory Division). October 2008
http://www.iafc.org/associations/4685/files/haz_IAFCmodelproceduresforbiohazardresponse.pdf