Archive for October, 2011

MMWR: Outbreaks of Rotavirus Gastroenteritis Among Elderly Adults

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6042a4.htm?s_cid=mm6042a4_e&source=govdelivery

Notes from the Field: Outbreaks of Rotavirus Gastroenteritis Among Elderly Adults in Two Retirement Communities — Illinois, 2011

WeeklyOctober 28, 2011 / 60(42);1456-1456

 

In February 2011, three residents of a retirement community in Illinois were hospitalized for acute gastroenteritis. The admitting physicians ordered testing of stool specimens for several pathogens, including rotavirus. The hospital laboratory detected rotavirus antigen in specimens from each patient, and the hospital infection control practitioner reported that information to the Cook County Department of Public Health. Two additional residents were hospitalized for rotavirus gastroenteritis shortly thereafter. The health department sent stool specimens from the five patients to CDC for testing for rotavirus and norovirus. Rotavirus was detected in each specimen; norovirus was not detected. During a subsequent investigation, all available residents were queried regarding recent diarrheal symptoms. Preliminary data indicated that 22% of residents had confirmed or probable rotavirus disease and 10 residents were hospitalized. In May 2011, another outbreak of rotavirus gastroenteritis was detected at a second retirement community in the county. On preliminary analysis, the overall attack rate in the second retirement community was 11%, and 20 residents were hospitalized. No deaths were identified in either outbreak. Based on preliminary results of the investigations and general knowledge of rotavirus transmission, within each community, rotavirus likely was transmitted from person to person via contaminated hands or fomites (e.g., environmental surfaces). The outbreaks lasted ≥4 weeks.

Rotavirus is well recognized as a major cause of severe gastroenteritis in young children. Rotavirus also can cause gastroenteritis in adults (1), but estimates of the disease burden are imprecise because rotavirus testing of adults rarely is performed. The extent to which rotavirus outbreaks occur among elderly adults in residential facilities (e.g., retirement communities and assisted living facilities) in the United States (2,3) also is unknown because rotavirus testing usually is not performed during outbreak investigations of diarrheal disease in these settings and rotavirus outbreaks are not nationally reportable. Norovirus, however, frequently has been reported as a cause of diarrhea outbreaks among elderly persons in assisted living or long-term–care facilities. From 1998 to 2000, CDC screened specimens from 263 gastroenteritis outbreaks (not restricted to outbreaks among elderly adults). Specimens from all but 32 (12%) of those outbreaks tested positive for norovirus, and rotavirus was identified as the causative agent in three of the remaining 32 outbreaks (1% of the overall 263 outbreaks) (3).

Health professionals who care for elderly persons in residential facilities or who investigate diarrheal disease outbreaks should consider rotavirus as a possible cause of acute diarrhea, especially during the months when rotavirus circulates (usually January to June). If an outbreak of rotavirus gastroenteritis is identified, good hand hygiene practices among residents and staff members should be reinforced. Environmental surfaces should be disinfected using a freshly made solution of 1 part household bleach to 2 parts water (providing approximately 20,000 ppm of free chlorine) or another product that has confirmed virucidal activity against rotavirus (4,5). Surfaces visibly contaminated with fecal material should be cleaned to remove the material and then disinfected. CDC is gathering information about rotavirus outbreaks among elderly adults in residential facilities. State and local public health agencies involved in these investigations of suspected or confirmed rotavirus outbreaks are encouraged to contact the CDC’s Division of Viral Diseases at 404-639-8253 begin_of_the_skype_highlighting 404-639-8253 end_of_the_skype_highlighting.

References

  1. Anderson EJ, Weber SG. Rotavirus infection in adults. Lancet Infect Dis 2004;4:91–9.
  2. Edmonson LM, Ebbert JO, Evans JM. Report of a rotavirus outbreak in an adult nursing home population. J Am Med Dir Assoc 2000;1:175–9.
  3. Griffin DD, Fletcher M, Levy ME, et al. Outbreaks of adult gastroenteritis traced to a single genotype of rotavirus. J Infect Dis 2002;185:1502–5.
  4. Rao GG. Control of outbreaks in viral diarrhoea in hospitals—a practical approach. J Hosp Infect 1995;30:1–6.
  5. Springthorpe VS, Grenier JL, Lloyd-Evans N, Sattar SA. Chemical disinfection of human rotaviruses: efficacy of commercially available products in suspension tests. J Hyg (Lond) 1986;97:139–61.

The danger of the newer OCs

http://www.medicalnewstoday.com/articles/236627.php

MNT

“….The newer kinds of pills, which contain the progestin hormones drospirenone, desogestrel, or gestodene along with estrogen, doubled the risk again, making it six to seven times as high as women who weren’t using hormonal forms of birth control. On average, roughly 10 out of 10,000 women taking newer kinds of birth control pills had venous thromboembolism within a year.

The study which is probably going to trouble doctors, patients and drug companies alike, was published in BMJ, just as the FDA is reviewing the safety of newer birth control pills. The FDA birth control investigation was announced in May 2011 and is scheduled to be finished shortly……”

NEJM study on RTS,S/AS01 Malaria Vaccine

http://www.nejm.org/doi/pdf/10.1056/NEJMoa1102287

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in
African Children

The RTS,S Clinical Trials Partnership

October 18, 2011 (10.1056/NEJMoa1102287)

An ongoing phase 3 study of the efficacy, safety, and immunogenicity of
candidate malaria vaccine RTS,S/AS01 is being conducted in seven African
countries.

The RTS,S/AS01 vaccine provided protection against both
clinical and severe malaria in African children.

CDC’s wild about new malaria vaccine

http://www.cdc.gov/media/releases/2011/s1018_malaria_vaccine.html?source=govdelivery

 

The Centers for Disease Control and Prevention
welcomes the announcement today that results from the clinical trial in Africa
of a malaria vaccine candidate show it prevented about half of malaria cases,
including the most severe, in young children.

 

The RTS,S/AS01 study results, published in the New England Journal of
Medicine, are a promising advance in development of a malaria vaccine for
African children, which, if successful, could save hundreds of thousands of
lives. In 2009, malaria caused the deaths of nearly 800,000 people;
approximately 90 percent were children in Africa.

 

Children ages 5-17 months were enrolled in the trial at 11 sites in seven
African countries. The children who received the vaccine had approximately half
the number of clinical and severe malaria cases than children in the comparison
group, which received other vaccines, either rabies or meningococcal. CDC, in
collaboration with the Kenya Medical Research Institute, led the trial at one
site in western Kenya.

 

Still to come are analyses of how well the RTS,S/AS01 vaccine works in young
infants (aged 6-12 weeks) when provided with their routine childhood
immunizations, and how long the vaccine is protective. Those data, expected in
2012 and 2014, respectively, will be critical to understanding how the vaccine
may be used to control malaria.

 

It’s important to note that the vaccine provided this protection in settings
where there is ongoing use of other effective malaria prevention and treatment
interventions: bed nets, antimalarial drugs, indoor residual insecticide
spraying to prevent mosquito-borne transmission, and drugs to protect pregnant
women and their fetuses from malaria’s adverse effects. Thanks to sharp
increases in global funding for malaria during the past decade, many African
countries have been able to scale up the distribution and use of these safe,
effective, and affordable life-saving interventions. As a result, many countries
have seen decreases of up to 50 percent in deaths of children younger than 5
years (PMI Fifth
Annual Report, April 2011
).  

 

The Roll Back Malaria Partnership, which includes
CDC, is working to achieve near zero preventable malaria deaths. These promising vaccine trial results add to the hope that
adding an effective vaccine to current malaria interventions will move us closer
to that goal.

 

Thomas R. Frieden, M.D., M.P.H.
Director, Centers for Disease Control and
Prevention
Administrator, Agency for Toxic Substances and Disease Registry.

RTS,S for malaria

http://www.usaid.gov/press/releases/2011/ps111018.html

FOR IMMEDIATE RELEASE
October 18, 2011
Public Information: 202-712-4810
www.usaid.gov

SEATTLE, WA. – Dr. Rajiv Shah, Administrator of the U.S. Agency for International Development (USAID), issued the following statement on behalf of the United States at the Bill and Melinda Gates Malaria Forum.

“At USAID, we welcome the initial news of the Phase 3 efficacy trial published today confirming the RTS,S malaria vaccine is safe and effective. The vaccine, as a new addition to our present package malaria control interventions, could result in further major reductions in severe malaria cases and deaths. RTS,S as a first generation vaccine is an important first step in collaborative efforts to develop the next generation of even more effective vaccines.

An effective vaccine is a critical component of an integrated approach to malaria control, and USAID remains committed to supporting their development.

Over the past five years, global action to combat malaria has saved an estimated 1.1 million lives in sub-Saharan Africa. African countries are now poised to achieve the first great humanitarian victory of the 21st century—near zero child deaths from malaria. To do so we will need the collaboration of all stakeholders at all levels.

The United States is committed to supporting historic gains against child mortality. This catalytic effort will build on the success and platforms of the Presidents Malaria Initiative, PEPFAR, and the Global Health Initiative, saving lives of mothers and children from a preventable and curable disease that once ravaged our own nation and creating an important legacy for this Administration. These efforts will also create a generation of healthy children who have the opportunity now to benefit from education, lead productive lives, and contribute to their countries’ development.

At a technical level, the United States will work through PMI and the Global Health Initiative to accelerate ending malaria as a major public health problem across sub-Saharan Africa by intensifying current control efforts and extending the reach of malaria interventions to under-served populations in the most highly affected countries.

This work includes scaling up existing efforts and accelerating the delivery of critical, cost-effective health services by integrating and expanding facility and community-based health care service delivery. We can save millions of lives by supporting community case management and scaling up approaches for the diagnosis and treatment of malaria, pneumonia, diarrhea and malnutrition, including community-based distribution of Vitamin A and deworming tablets.

The United States Government is totally committed to the fight against malaria and will continue to work with partners to achieve the goal of removing malaria as a public health burden.

Ocean City, MD: Legionella at the Plim Plaza Hotel

http://www.dhmh.state.md.us/pressreleases/2011/pr101211.html

Maryland Department of Health and Mental Hygiene, Press Release

10/12/11

Ocean City, MD (October 12, 2011) – Maryland Department of Health and Mental Hygiene (DHMH) Laboratories Administration testing confirmed the presence of Legionella bacteria in water collected at the Plim Plaza Hotel in Ocean City, Maryland. Legionella pneumophila, the bacteria that cause Legionnaires’ disease, was detected in water collected from various locations at the hotel.

An ongoing investigation by the Worcester County Health Department and DHMH has identified three additional cases of Legionnaires’ disease in people who had stayed at the hotel. This is in addition to the three cases announced by the health department last week, for a total of six confirmed cases. One person, an elderly out-of-state resident, died. The Worcester County Health Department and DHMH continue to work with the Plim Plaza Hotel management to investigate this situation.

Legionnaires’ disease, also called legionellosis, is a form of pneumonia caused by inhaling mist or vapor from water containing the Legionella bacteria. People may develop the disease approximately two to 14 days following exposure to the bacteria.

Although the hotel is currently closed for the season, anyone who was a guest at the Plim Plaza hotel in the month of September and is experiencing pneumonia-like symptoms should contact his or her health care provider to determine whether testing or treatment is recommended. The disease can be treated with commonly available antibiotics. Legionellosis is not spread from person to person.

There have been 93 confirmed cases of Legionnaires’ disease reported this year in Maryland. On average 100 -130 cases are reported statewide annually.

Philly EMS: Overworked and Under stress

http://www.ems1.com/ems-management/articles/1165510-Report-Philly-medics-overworked-system-stressed/

 Report: Philly medics overworked, system stressed

 

PHILADELPHIA — “Four years ago, City Controller Alan Butkovitz released a report revealing a Philadelphia EMS system in crisis: Sick people waiting too long for ambulances; paramedics dangerously overworked; and non-emergency calls overwhelming the system.

The report echoed the pleas of paramedics who had long called for change, and recommended steps to relieve pressure on the stressed 911 system.

Four years later, little has changed, Butkovitz said Wednesday as he released a follow-up audit that analyzed Fire Department data from 2009…..”

DWI-FLAIR mismatch

http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2811%2970192-2/fulltext

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study
Dr Götz Thomalla MD,Bastian Cheng MD,Martin Ebinger MD,Qing Hao MD,Prof Thomas Tourdias MD,Ona Wu PhD,Prof Jong S Kim MD,Lorenz Breuer MD,Oliver C Singer MD,Prof Steven Warach MD,Soren Christensen PhD,Andras Treszl MSc,Nils D Forkert MSc,Ivana Galinovic MD,Michael Rosenkranz MD,Prof Tobias Engelhorn MD,Martin Köhrmann MD,Prof Matthias Endres MD,Prof Dong-Wha Kang MD,Prof Vincent Dousset MD,Prof A Gregory Sorensen MD,Prof David S Liebeskind MD,Jochen B Fiebach MD,Prof Jens Fiehler MD,Prof Christian Gerloff MD,for the STIR and VISTA Imaging Investigators
The Lancet Neurology – 5 October 2011
DOI: 10.1016/S1474-4422(11)70192-2
“Patients with an acute ischaemic lesion detected with DWI but not with FLAIR imaging are likely to be within a time window for which thrombolysis is safe and effective. These findings lend support to the use of DWI-FLAIR mismatch for selection of patients in a future randomised trial of thrombolysis in patients with unknown time of symptom onset.”

It’s a long, long way to a trauma center…..

http://www.wtop.com/?nid=267&sid=2578644

Wednesday – 10/5/2011, 4:11pm  ET

By RICARDO ALONSO-ZALDIVAR
Associated Press 

WASHINGTON (AP) – “…….about a quarter of Americans now have to travel farther to reach the nearest hospital trauma center….

The reason: Hundreds of trauma centers have closed over the past two decades.

Sixty-nine million people had to travel farther to reach a trauma center in 2007 than in 2001, according a study in the journal Health Affairs.

The median _ or midpoint _ increase in travel time was 10 minutes. But for nearly 16 million people, travel times increased by 30 minutes or longer….”