Uchino K, Hernandez A “Dabigatran association with higher risk of acute coronary events” Arch Intern Med 2012; DOI: 10.1001/archinternmed.2011.1666.

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Dabigatran Association With Higher Risk of Acute Coronary Events

Meta-analysis of Noninferiority Randomized Controlled Trials

Ken Uchino, MD; Adrian V. Hernandez, MD, Phd

Arch Intern Med. Published online January 9, 2012. doi:10.1001/archinternmed.2011.1666

http://archinte.ama-assn.org/cgi/content/full/archinternmed.2011.1666

Conclusions Dabigatran is associated with an increased risk of MI or ACS in a broad spectrum of patients when tested against different controls. Clinicians should consider the potential of these serious harmful cardiovascular effects with use of dabigatran.